| May 1st
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- Mother Goose Day
- May Day
- National Day of Prayer (first Thursday in May)
- National Day of Reason (first Thursday in May)
- Law Day
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| May 2nd
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- Brothers & Sisters Day
- National Peanut Butter & Jelly Day
- No Pants Day (first Friday in May)
- Space Day (first Friday in May)
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| May 3rd
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- Lumpy Rug Day
- World Press Freedom Day
- Pilates Day
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| May 4th
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- Motorcycle Mass & Blessing of the Bikes Day
- Renewal Day
- Respect for Chickens Day
- International Star Wars Day
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| May 5th
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| May 6th
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- Teacher's Day
- No Homework Day
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| May 7th
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- National School Nurse Day (Always the Wednesday of National Nurse Week)
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| May 8th
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| May 9th
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| May 10th
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| May 11th
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- Twilight Zone Day
- Eat What You Want Day
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| May 12th
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| May 13th
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| May 14th
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| May 15th
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- Chocolate Chip Day
- National Sea Monkey Day
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| May 16th
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- National Bike/Walk to Work Day
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| May 17th
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- Armed Forces Day
- Pack Rat Day
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| May 18th
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- International Museum Day
- Stepmother's Day (always the Sunday after Mother's Day)
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| May 19th
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| May 20th
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| May 21st
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| May 22nd
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- National Maritime Day
- Buy a Musical Instrument Day
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| May 23rd
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| May 24th
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- International Jazz Day(always the Saturday before Memorial Day)
- National Escargot Day
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| May 25th
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- National Tap Dance Day
- Nerd Pride Day or Geek Pride Day
- Towel Day
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| May 26th
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| May 27th
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| May 28th
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- National Senior Fitness Day
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| May 29th
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| May 30th
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- National Mint Julep Day
- Water a Flower Day
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| May 31st
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- National Save Your Hearing Day
- National Macaroon Day
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